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Article

RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation

15 May 2018

Abstract excerpt

Myofibroblasts play key roles in wound healing and pathological fibrosis. Here, we used an RNAi screen to characterize myofibroblast regulatory genes, using a high-content imaging approach to quantify α-smooth muscle actin stress fibers in cultured human fibroblasts. Screen hits were validated on physiological compliance hydrogels, and selected hits tested in primary fibroblasts from patients with idiopathic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29678906
DOI: 10.1242/jcs.209932

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