Article

Precise removal of <i>Calm1</i> long 3′ UTR isoform by CRISPR-Cas9 genome editing impairs dorsal root ganglion development in mice

2019-02-18

Abstract excerpt

Most mammalian genes are subject to Alternative cleavage and PolyAdenylation (APA), often resulting in alternative length 3′ UTR isoforms. Thousands of extended or long 3′ UTR variants are preferentially expressed in neuron-enriched tissues of metazoans. However, the in vivo functions of these long 3′ UTR isoforms are largely unknown. Calmodulin 1 ( Calm1) is a key integrator of calcium signaling that is requir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22760fbb-9405-52a7-a442-b8668ed86172
DOI: 10.1101/553990

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Precise removal of <i>Calm1</i> long 3′ UTR isoform by CRISPR-Cas9 genome editing impairs dorsal root ganglion development in miceDOI 10.1101/553990Read

The role of <i>Limch1</i> alternative splicing in skeletal muscle functionSemantic proximity Read

Reversal of molecular pathology by RNA-targeting Cas9 in a myotonic dystrophy mouse modelSemantic proximity Read

The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster.Semantic proximity Read

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.Semantic proximity Read

CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report.Semantic proximity Read

Conditional knockouts generated by engineered CRISPR-Cas9 endonuclease reveal the roles of coronin in C. elegans neural development.Semantic proximity Read

CRISPR/Cas9 interrogation of the mouse <i>Pcdhg</i> gene cluster reveals a crucial isoform-specific role for <i>Pcdhgc4</i>Semantic proximity Read

Alternative splicing of <i>SORBS1</i> affects neuromuscular junction formation and stability in myotonic dystrophy type 1Semantic proximity Read

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylationSemantic proximity Read

The <i>kpc-1</i> 3’UTR facilitates dendritic transport and translation of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtshipSemantic proximity Read

The mammalian Kalrn locus gives rise to several novel long non-coding RNAsSemantic proximity Read

Mouse Gnal transcripts and transcriptomics in isolated dystoniaSemantic proximity Read