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Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

22 Apr 2020

Abstract excerpt

We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease, we generated Nudt21+/- mice to mimic NUDT21-deletion patients. We found that although these mice have 50% reduced Nudt21 mRNA, they only have 30% less of...

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PMID: 32319885
DOI: 10.7554/elife.50895

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