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Article

BIN1 favors the spreading of Tau via extracellular vesicles

1 Jul 2019

Abstract excerpt

Despite Bridging INtegrator 1 (BIN1) being the second most statistically-significant locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis remains to be clarified. As reports suggest a link between BIN1, Tau and extracellular vesicles, we investigated whether BIN1 could affect Tau spreading via exosomes secretion. We observed that BIN1-associated Tau-containing extracellular...

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PMID: 31263146
DOI: 10.1038/s41598-019-45676-0

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