Article
Nuclear pore components affect distinct stages of intron-containing gene expression.
Nucleic acids research - 30 Apr 2015
Bonnet Amandine, Bretes Hugo, Palancade Benoit
Abstract excerpt
Several nuclear pore-associated factors, including the SUMO-protease Ulp1, have been proposed to prevent the export of intron-containing messenger ribonucleoparticles (mRNPs) in yeast. However, the molecular mechanisms of this nuclear pore-dependent mRNA quality control, including the sumoylated targets of Ulp1, have remained unidentified. Here, we demonstrate that the apparent 'pre-mRNA leakage' phenotype...
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