Article

NXT2 is the key player for nuclear RNA export in the human testis and critical for spermatogenesis

2024-08-02

Abstract excerpt

In eukaryotes, the nucleocytoplasmic export of bulk poly(A) + -mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In humans, NXT1 has an X-chromosomal paralog, NXT2, which exhibits testis-enriched expression, suggesting a role in spermatogenesis. Here, we report the in vivo interaction of NXT2 with crucial components of the nuclear export machinery, including NX...

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Literature Corpus work: 5438ebf2-0146-5715-b7dd-2decc49ff27c
DOI: 10.1101/2024.08.01.24310552

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