Article

Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability

2018-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Can transcriptomic alterations drive the evolution of tumors? We rationalize that expressional changes found in all patients arise earlier in tumor development compared to alterations that occur only in limited subsets of patients. Our analyses of non-mutated genes from the non-amplified regions of the genome of 158 triple negative breast cancer (TNBC) cases identified 219 exclusively expression...

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Literature Corpus work: 22412980-20df-5615-8d4a-ebb2d2635f58
DOI: 10.1101/333633

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