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Article

Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2.

PLoS biology - 1 Dec 2021

Castiglione Gianni M, Zhou Lingli, Xu Zhenhua, Neiman Zachary, Hung Chien-Fu, Duh Elia J

Abstract excerpt

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted, binding a diversity of angiotensin converting enzyme 2 (ACE2) orthologs despite extensive sequence divergence. Within this sequence degeneracy, we identify a rare sequence combination capable of conferring SARS-CoV-2 resistance. We demonstrate that this sequence was likely...

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Identifiers

PMID: 34932561
DOI: 10.1371/journal.pbio.3001510
PMCID: PMC8730403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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