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ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2

1 Jan 2020

Abstract excerpt

The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to identify variations and contribute to the understanding of evolutionary dynamics behind this successful adaptation to infect humans. Our results reveal that 4%...

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PMID: 32520981
DOI: 10.1590/1678-4685-gmb-2020-0104

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