Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.

doi:10.1073/pnas.2010146117

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Article

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2020

Damas Joana, Hughes Graham M, Keough Kathleen C, Painter Corrie A, Persky Nicole S, Corbo Marco, Hiller Michael, Koepfli Klaus-Peter, Pfenning Andreas R, Zhao Huabin, Genereux Diane P, Swofford Ross, Pollard Katherine S, Ryder Oliver A, Nweeia Martin T, Lindblad-Toh Kerstin, Teeling Emma C, Karlsson Elinor K, Lewin Harris A

Abstract excerpt

The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32826334
DOI: 10.1073/pnas.2010146117
PMCID: PMC7486773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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