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Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

2 Feb 2023

Abstract excerpt

ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance; as a chaperone, it controls intestinal amino acid uptake. ACE2's tissue distribution, affected by co-morbidities and sex,...

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PMID: 36787743
DOI: 10.1016/j.cell.2023.01.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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