Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ACE2 isoform diversity predicts the host susceptibility of SARS-CoV-2.

Transboundary and emerging diseases - 1 May 2021

Gao Shan, Luan Junwen, Cui Haoran, Zhang Leiliang

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2. In our current study, we found that two types of deficient ACE2 isoforms from different mammals compete with full-length ACE2 for association with S protein. One type of ACE2 is a natural soluble isoform, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Mammals

Share to Protein Binding

Share to SARS-CoV-2

Share to Species Specificity

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 32757470
DOI: 10.1111/tbed.13773
PMCID: PMC7436438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ACE2 isoform diversity predicts the host susceptibility of SARS-CoV-2.PMID 32757470Read ↗

Integrate structural analysis, isoform diversity, and interferon-inductive propensity of ACE2 to predict SARS-CoV2 susceptibility in vertebratesSemantic proximity Read ↗

ACE2 partially dictates the host range and tropism of SARS-CoV-2Semantic proximity Read ↗

Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in VertebratesSemantic proximity Read ↗

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.Semantic proximity Read ↗

Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species.Semantic proximity Read ↗

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2Semantic proximity Read ↗

Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2.Semantic proximity Read ↗

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2Semantic proximity Read ↗

The ancient cardioprotective mechanisms of ACE2 bestow SARS-CoV-2 with a wide host rangeSemantic proximity Read ↗

A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: implications for future surveillance programmesSemantic proximity Read ↗

Comparative analyses of ACE2 and TMPRSS2 gene: Implications for the risk to which vertebrate animals are susceptible to SARS-CoV-2.Semantic proximity Read ↗

Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.