Article

Switching Strategies to Mitigate HIV Mutation

2013-09-24

Abstract excerpt

HIV mutates rapidly and may develop resistance to specific drug therapies. There is no general agreement on how to optimally schedule the available treatments for mitigating the effects of mutations. With a switched positive linear system, we examined different control strategies applied to a higher order nonlinear mutation model. Simulation results suggest that model predictive control could outperform the common...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2228e89a-294c-551a-88b7-a50927b325aa
DOI: 10.1109/tcst.2013.2280920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Switching Strategies to Mitigate HIV MutationDOI 10.1109/tcst.2013.2280920Read

Discrete‐time control for switched positive systems with application to mitigating viral escapeSemantic proximity Read

Dynamic multidrug therapies for HIV: a control theoretic approach.Semantic proximity Read

Optimal Antiviral Switching to Minimize Resistance Risk in HIV TherapySemantic proximity Read

A Scalable Formulation for Engineering Combination Therapies for Evolutionary Dynamics of DiseaseSemantic proximity Read

Virus dynamic behavior of a stochastic HIV/AIDS infection model including two kinds of target cell infections and CTL immune responsesSemantic proximity Read

Precision Elimination: Proof-of-Concept In Silico Testing of a Novel Construct for Optimizing HIV-1 EradicationSemantic proximity Read

Systems mapping of HIV-1 infection.Semantic proximity Read

Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects.Semantic proximity Read

Autonomous targeting of infectious superspreaders using engineered transmissible therapies.Semantic proximity Read

Management of antiretroviral therapy for HIV infection: modelling when to change therapy.Semantic proximity Read

Mathematical analysis of a class of HIV infection models of CD4+ T-cells with combined antiretroviral therapySemantic proximity Read

Multi-scale modeling of HIV infection in vitro and APOBEC3G-based anti-retroviral therapy.Semantic proximity Read