Article
Management of antiretroviral therapy for HIV infection: modelling when to change therapy.
Antiviral therapy - 1 Jan 1998
D'Amato R M, D'Aquila R T, Wein L M
Abstract excerpt
OBJECTIVE: To evaluate four strategies for monitoring plasma HIV RNA levels and/or resistance genotypes to decide when to change antiretroviral therapy. The strategies include: (i) 1997 guidelines recommending a therapy switch when plasma RNA exceeds a threshold level; (ii) a viral load policy, using a fixed increase in viral load as the trigger; (iii) a genotype policy, requiring a smaller viral rebound than...
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