Article

Precision Elimination: Proof-of-Concept In Silico Testing of a Novel Construct for Optimizing HIV-1 Eradication

2025-03-28

Abstract excerpt

<h4>Background: </h4> /Objectives: Human immunodeficiency virus type 1 (HIV-1) persists in individuals on combination antiretroviral therapy (cART) due to the existence of latent reservoirs that evade immune detection. Although shock-and-kill strategies utilizing latency-reversing agents (LRAs) aim to reactivate and eliminate these reservoirs, their effectiveness is limited by cART's lack of cytotoxicity, which me...

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Literature Corpus work: df9204b2-ec68-5824-abf5-99908b240947
DOI: 10.20944/preprints202503.0071.v2

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