Article
A Scalable Formulation for Engineering Combination Therapies for Evolutionary Dynamics of Disease
2013-11-07
Abstract excerpt
It has been shown that optimal controller synthesis for positive systems can be formulated as a linear program. Leveraging these results, we propose a scalable iterative algorithm for the systematic design of sparse, small gain feedback strategies that stabilize the evolutionary dynamics of a generic disease model. We achieve the desired feedback structure by augmenting the optimization problems with ℓ 1 and ℓ 2...
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Identifiers and source
- Literature Corpus work
- fdfa77f3-9c30-5a1d-9297-a39b222e5211
- DOI
- 10.1101/000075