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Article

Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma

20 Jul 2020

Abstract excerpt

Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result, novel treatment strategies are needed for relapse and refractory neuroblastoma patients. Here, we found that high expression of Mps1 kinase (mitotic kinase Monopolar Spindle 1) was associated with relapse-free neuroblastoma patient outcomes and...

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Share to Cell death mechanisms and regulation
Share to Microtubule and mitosis dynamics
Share to Neuroblastoma Research and Treatments

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PMID: 32686724
DOI: 10.1038/s41598-020-68829-y

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