Article

A comparison of mtDNA deletion mutant proliferation mechanisms

2022-05-04

Abstract excerpt

In this paper we use simulation methods to investigate the proliferation of deletion mutations of mitochondrial DNA in neurons. We simulate three mtDNA proliferation mechanisms, namely, random drift, replicative advantage and vicious cycle. For each mechanism, we investigated the effect mutation rates have on neuron loss within a human host. We also compare heteroplasmy of each mechanism at mutation rates that yie...

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Literature Corpus work: 21ccbd1a-4c74-54a1-a084-32bf98fe1b71
DOI: 10.1101/2022.05.03.489489

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