Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Abstract excerpt

Treatment-refractory rheumatoid arthritis (RA) is a major unmet need, and the mechanisms driving treatment resistance are poorly understood. To identify molecular determinants of RA non-remission, we performed spatial transcriptomic profiling on pre- and post-treatment synovial tissue biopsies from treatment naïve patients who received conventional DMARDs or adalimumab for 6 months. In the baseline biopsies of non...

Topics

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• Autoimmune and Inflammatory Disorders Research
• Lymphoma Diagnosis and Treatment
• NF-κB Signaling Pathways
• Rheumatoid Arthritis Research and Therapies
• Systemic Lupus Erythematosus Research

Identifiers and source

Literature Corpus work

21b9a0af-bd1a-5712-afe5-2c8c1b7501e5

DOI

10.1101/2025.03.14.642821