Article

ARID5B drives an inflammatory-to-destructive shift in pathologic fibroblast behavior

2026-08-10

Abstract excerpt

During inflammatory diseases such as rheumatoid arthritis, fibroblasts prominently drive chronic inflammation and the subsequent destruction of cartilage and bone. The mechanism by which an activated, inflammatory fibroblast acquires tissue destructive behaviors is unknown. Here, we describe ARID5B as a transcription factor that directs inflammatory fibroblasts to become migratory and invasive. Upon upregulation i...

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Literature Corpus work: a6247fec-ecfd-566e-b152-9acb89b135e5
DOI: 10.64898/2026.08.04.742822

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