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Article

Wnt signaling drives stromal inflammation in inflammatory arthritis

2025-01-08

Abstract excerpt

The concept that fibroblasts are critical mediators of inflammation is an emerging paradigm. In rheumatoid arthritis (RA), they are the main producers of IL-6 as well as a host of other cytokines and chemokines. Their pathologic activation also directly causes cartilage and bone degradation. Yet, therapeutic agents specifically targeting fibroblasts are not available. Here, we find that Wnt receptors and modulator...

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Literature Corpus work
2c1d0a34-5b67-5595-8095-cc3777addccd
DOI
10.1101/2025.01.06.631510
Open publication

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Wnt signaling drives stromal inflammation in inflammatory arthritisDOI 10.1101/2025.01.06.631510
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