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Article

ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.

Haematologica - 1 May 2016

Arashiki Nobuto, Takakuwa Yuichi, Mohandas Narla, Hale John, Yoshida Kenichi, Ogura Hiromi, Utsugisawa Taiju, Ohga Shouichi, Miyano Satoru, Ogawa Seishi, Kojima Seiji, Kanno Hitoshi

Abstract excerpt

Phosphatidylserine is localized exclusively to the inner leaflet of the membrane lipid bilayer of most cells, including erythrocytes. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized phosphatidylserine is a phagocytic signal for splenic macrophages. Flippases are P-IV ATPase family proteins that actively transport phosphatidylserine from the outer to...

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Share to Adenosine Triphosphatases
Share to Anemia, Hemolytic, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26944472
DOI: 10.3324/haematol.2016.142273
PMCID: PMC5004368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.PMID 26944472Read ↗

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