Article
CRISPR-edited megakaryocytes for rapid screening of platelet gene functions.
Blood advances - 11 May 2021
Montenont Emilie, Bhatlekar Seema, Jacob Shancy, Kosaka Yasuhiro, Manne Bhanu K, Lee Olivia, Parra-Izquierdo Ivan, Tugolukova Emilia, Tolley Neal D, Rondina Matthew T, Bray Paul F, Rowley Jesse W
Abstract excerpt
Human anucleate platelets cannot be directly modified using traditional genetic approaches. Instead, studies of platelet gene function depend on alternative models. Megakaryocytes (the nucleated precursor to platelets) are the nearest cell to platelets in origin, structure, and function. However, achieving consistent genetic modifications in primary megakaryocytes has been challenging, and the functional effects...
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