Article

Crystal structure of a human plasma membrane phospholipid flippase

2019-12-27

Abstract excerpt

ATP11C, a member of P4-ATPase flippase, exclusively translocates phosphatidylserine from the outer to the inner leaflets of the plasma membrane, and maintains the asymmetric distribution of phosphatidylserine in the living cell. However, the mechanisms by which ATP11C translocates phosphatidylserine remain elusive. Here we show the crystal structures of a human plasma membrane flippase, ATP11C-CDC50A complex, in a...

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Literature Corpus work: dcfa81c1-79d9-51ef-b49a-d6b3b13375f3
DOI: 10.1101/2019.12.23.881698

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