Article

Metabolic defects cause hyperactive mitochondria and Parkinson’s disease-like traits

2020-02-22

Abstract excerpt

Metabolic dysfunction is a facet of many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood 1 . We recently discovered a potential causal link between the branched-chain amino acid transferase, BCAT-1 , and the neurodegenerative movement disorder, Parkinson’s disease (PD) 2 . Knockdown of C. elegans bcat-1 recapitulates PD-like features, including progressive mot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c0b3d4f-c296-5d44-91bc-61070b1577a9
DOI: 10.1101/2020.02.20.958322

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic defects cause hyperactive mitochondria and Parkinson’s disease-like traitsDOI 10.1101/2020.02.20.958322Read

Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria.Semantic proximity Read

Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseasesSemantic proximity Read

Modeling Parkinson's Disease in C. elegans.Semantic proximity Read

Molecular insights into Parkinson's disease and type 2 diabetes mellitus: Metformin's role and genetic pathways exploredSemantic proximity Read

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1Semantic proximity Read

A metabolic signature for long life in the Caenorhabditis elegans Mit mutants.Semantic proximity Read

Small Molecule Stabilization of PINK-1/PINK1 Improves Neurodegenerative DiseaseSemantic proximity Read

Traversing a wormhole to combat Parkinson's disease.Semantic proximity Read

Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.Semantic proximity Read

Unraveling Parkinson’s Disease Neurodegeneration: Does Aging Hold the Clues?Semantic proximity Read

GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a <i>C. elegans</i> model of Parkinson’s diseaseSemantic proximity Read

Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction.Semantic proximity Read