Article

Sleep and Diurnal Rest-Activity Rhythm Disturbances in a Mouse Model of Alzheimer’s Disease

2020-02-18

Abstract excerpt

<h4>Study Objectives</h4> Accumulating evidence suggests a strong association between sleep, amyloid-beta (Aβ) deposition, and Alzheimer’s disease (AD). We sought to determine if: (1) deficits in rest-activity rhythms and sleep are significant phenotypes in J20 AD mice, (2) metabotropic glutamate receptor 5 inhibitors (mGluR 5 ) could rescue deficits in rest-activity rhythms and sleep, and (3) Aβ levels are resp...

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Identifiers and source

Literature Corpus work: 74ec2c68-d454-5222-a326-733ae5e3467d
DOI: 10.1101/2020.02.17.950600

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