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Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity

2025-07-27

Abstract excerpt

<title>Abstract</title> <p> Parkinson’s disease (PD) is histopathologically defined by the presence of Lewy bodies, which are intracellular proteinaceous inclusions that contain mainly aggregated alpha-synuclein (aSyn). It is believed that oligomeric intermediates between monomeric aSyn and large aggregates are neurotoxic, which would lead to the demise of dopaminergic neurons. Therefore, novel therapies prevent...

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Literature Corpus work
217efc83-c639-5802-85ba-557a43a43670
DOI
10.21203/rs.3.rs-6867964/v1
Open publication

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Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicityDOI 10.21203/rs.3.rs-6867964/v1
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