Article

<i>TGFB1</i> rs8179181 polymorphism is reproducibly associated with Parkinson’s disease in a Spanish population

2022-07-11

Abstract excerpt

<h4>ABSTRACT</h4> There is evidence that transforming growth factor (TGF)-β signaling participates in the pathology of Parkinson’s disease (PD). Dampened TGF-β signaling in Smad3- or TβRII-deficient mice leads to the appearance of α-synuclein inclusions in the brain, as well as dopaminergic, motor, and cognitive deficits. Accordingly, we hypothesized that genetic variants of TGFB / SMAD could be risk factors for P...

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Literature Corpus work: 9b837804-26ad-5fd2-a41c-737af37c84b5
DOI: 10.1101/2022.07.09.22277447

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<i>TGFB1</i> rs8179181 polymorphism is reproducibly associated with Parkinson’s disease in a Spanish populationDOI 10.1101/2022.07.09.22277447Read

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