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Article

Transforming Growth Factor-&#946; Signaling in Motor Neuron Diseases

31 Jan 2011

Abstract excerpt

Transforming growth factor β (TGF-β), a pleiotropic cytokine, regulates a diverse range of cellular responses, such as proliferation, differentiation, migration, and apoptosis. The TGF-β1, -β2, and -β3 isoforms are expressed by neurons and glial cells, and their receptors are expressed throughout the central nervous system. Several lines of evidence demonstrate that TGF-β signaling protects neurons from glutamate...

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PMID: 21189118
DOI: 10.2174/156652411794474356

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