Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Role for TGF-&#946; Signaling in Neurodegeneration: Evidence from Genetically Engineered Models

30 Nov 2006

Abstract excerpt

Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD) afflict growing numbers of people but treatments are not available or ineffective. These diseases are characterized by the loss of specific neuronal populations, the accumulation of protein aggregates inside and sometimes outside neurons, and an activation of immune pathways in the brain. The causes of sporadic forms of AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GDF15 and Related Biomarkers
Share to Medicinal Plants and Bioactive Compounds

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17168649
DOI: 10.2174/156720506779025297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Role for TGF-&#946; Signaling in Neurodegeneration: Evidence from Genetically Engineered ModelsPMID 17168649Read ↗

Dysfunction of TGF-β1 signaling in Alzheimer’s disease: perspectives for neuroprotectionSemantic proximity Read ↗

Transforming Growth Factor-&#946; Signaling in Motor Neuron DiseasesSemantic proximity Read ↗

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of PathologySemantic proximity Read ↗

Ectopic expression of phospho‐Smad2 in Alzheimer's disease: Uncoupling of the transforming growth factor‐β pathway?Semantic proximity Read ↗

Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicitySemantic proximity Read ↗

APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis.Semantic proximity Read ↗

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

TGF-β and the regulation of neuron survival and deathSemantic proximity Read ↗

Role of the Insulin-like Growth Factor System in Neurodegenerative DiseaseSemantic proximity Read ↗

Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.Semantic proximity Read ↗

Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic MiceSemantic proximity Read ↗

Targeting Alzheimer's disease with gene and cell therapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.