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A Non-Coding Variant in <i>SLC15A4</i> Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility

2023-07-29

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic basis. Despite the identification of several single nucleotide polymorphisms (SNPs) near the SLC15A4 gene that are significantly associated with SLE across multiple populations, specific causal SNP(s) and molecular mechanisms responsible for disease susceptibility are unknown. To address this gap, we employed bioinformatics,...

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Literature Corpus work
217163e3-3723-5728-9a37-e607ecd54ccf
DOI
10.1101/2023.07.28.551056
Open publication

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A Non-Coding Variant in <i>SLC15A4</i> Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus SusceptibilityDOI 10.1101/2023.07.28.551056
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