Article

Effect of Lys84 carbamylation and chloride ion on OXA-143 dynamics and catalytic efficiency

2025-10-28

Abstract excerpt

Carbapenem-hydrolyzing Class-D β-lactamase OXA-143 is known as an efficient carbapenemase, and the number of clinically isolated Acinetobacter baumannii carrying the OXA-143 gene has risen significantly since it was first identified in 2004. The inhibitory effect of chloride ions on OXA enzymes has been described in the literature; however, no study has been performed on the OXA-143 subfamily. Furthermore, there...

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Literature Corpus work: 2165de39-fb7c-5839-9ec9-1f00657d185c
DOI: 10.1101/2025.10.27.684880

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