Exploring the coupling of dynamic residues in TEM-1 β-lactamase and their role in activity.

Abstract excerpt

The increase in the incidence of β-lactamase enzymes resistant to inhibitors has elevated the search for novel therapeutic strategies, particularly those that target amino acid residues other than the active site. In this respect, correlated amino acids that tend to evolve and have direct or indirect communication with the active site are considered potential candidates. Thus, this study identified residues that...

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