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Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases

2020-01-27

Abstract excerpt

β-lactamase mediated antibiotic resistance threatens treatment of bacterial infections. OXA-48 enzymes are clinically important class D serine β-lactamases (SBLs) that confer resistance to most β-lactam antibiotics, including carbapenems. However, OXA-48 and related enzymes vary widely in their activity towards different substrates: OXA-48 primarily hydrolyzes carbapenems, whereas the OXA-163 variant is a ce...

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Literature Corpus work
9b3751db-3f29-5961-8d60-3bb1b4344c58
DOI
10.26434/chemrxiv.11734074.v1
Open publication

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Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-LactamasesDOI 10.26434/chemrxiv.11734074.v1
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