Article

Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D β-lactamases

2022-12-20

Abstract excerpt

Oxacillinase (OXA)-48-like carbapenemases are epidemic class D β-lactamases in Enterobacterales , resulting in high mortality. Though the chemical mechanism has been clearly established, for decades, the link between the biphasic kinetic behaviour of these enzymes, which significantly impacts antibiotic efficacy, and the state of carbamylated lysine has been elusive. Here, substituting N- carbamylated lysine73 w...

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Literature Corpus work: 7e5800a3-c59b-5878-ad0e-c00096a877ce
DOI: 10.1101/2022.12.20.520813

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