Article

Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases

2020-05-04

Abstract excerpt

β-Lactamase mediated antibiotic resistance threatens treatment of bacterial infections. OXA-48 enzymes are clinically important class D serine β-lactamases (SBLs) that confer resistance to most β-lactam antibiotics, including carbapenems. However, OXA-48 and related enzymes vary widely in their activity toward different substrates: OXA-48 primarily hydrolyzes carbapenems, whereas the OXA-163 variant is a cephalosp...

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Literature Corpus work: 559f9a1a-16b4-5f7c-87d5-ad1b4ed8ab94
DOI: 10.1021/acscatal.0c00596

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