Article

Spatial transcriptomics exploration of the primary neuroblastoma microenvironment unveils novel paracrine interactions

2024-12-22

Abstract excerpt

<h4>ABSTRACT</h4> High-risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single-cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about local signaling dynamics. To address this gap, we profiled untreated and chemotherapy-treated high-risk neuroblastomas from 2 patients using spatial transcriptomi...

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Literature Corpus work: cc6a90f8-6089-51a3-997c-181faff03148
DOI: 10.1101/2024.12.21.629891

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