Article

Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients

2026-05-31

Abstract excerpt

<h4>Background</h4> Bispecific T-cell Engagers (TCEs) targeting B7H3 (CD276) show promise for solid tumors but are limited by systemic toxicities and poor tumor penetration. Intratumoral (IT) delivery is proposed as a solution, but the safety and spatial pharmacodynamics (PD) remain poorly defined in these malignancies. Spontaneous canine tumors serve as a highly translatable model for human therapeutic developme...

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Literature Corpus work: b8559331-0f59-515f-ac79-0f79c4ca582d
DOI: 10.64898/2026.05.27.728355

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