Tumor‐infiltrating gamma delta T‐cells reveal exhausted subsets with remarkable heterogeneity in colorectal cancer

Abstract excerpt

Abstract The γδT‐cells recognize infected or transformed cells. However, unlike αβT‐cells, γδT‐cells are innate‐like immune cells, with no major histocompatibility complex restriction requirements. γδT‐cells are the main population of intestinal intraepithelial lymphocytes (IELs) and are associated with the antitumor immune response, particularly in colorectal cancer (CRC). Although CD8 + T‐cells exhibit...

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