Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer.

Frontiers in immunology - 1 Jan 2021

DiToro Daniel, Basu Rajatava

Abstract excerpt

The intestinal immune system has the difficult task of protecting a large environmentally exposed single layer of epithelium from pathogens without allowing inappropriate inflammatory responses. Unmitigated inflammation drives multiple pathologies, including the development of colorectal cancer. CD4+T cells mediate both the suppression and promotion of intestinal inflammation. They comprise an array of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Differentiation
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Plasticity

Share to Colorectal Neoplasms

Share to Gene Expression Regulation, Neoplastic

Share to Lymphocytes, Tumor-Infiltrating

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34489941
DOI: 10.3389/fimmu.2021.694833
PMCID: PMC8417887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer.PMID 34489941Read ↗

Gut γδ T cells as guardians, disruptors, and instigators of cancerSemantic proximity Read ↗

Immunologic Drivers and Restraints in Colitis-Associated Colorectal CancerSemantic proximity Read ↗

Dissecting the mechanisms of intestinal immune homeostasis by analyzing T-cell immune response in Crohn's disease and colorectal cancerSemantic proximity Read ↗

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells.Semantic proximity Read ↗

Treg subsets in inflammatory bowel disease and colorectal carcinoma: Characteristics, role, and therapeutic targets.Semantic proximity Read ↗

The clinical implications of immunogenomics in colorectal cancer: A path for precision medicineSemantic proximity Read ↗

The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer.Semantic proximity Read ↗

Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient’s survival and immunotherapy responsivenessSemantic proximity Read ↗

Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease.Semantic proximity Read ↗

Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel diseaseSemantic proximity Read ↗

Immunogenomic Classification of Colorectal Cancer and Therapeutic ImplicationsSemantic proximity Read ↗

Dual Roles for Immunity in Gastrointestinal CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.