Article

DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers

2023-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation that is aberrantly expressed in a small subset of primary tumors. Here, we report that DUX4 expression is a common feature of metastatic tumors, with ∼...

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Literature Corpus work: 211b159e-a3cd-591c-a338-7432808d33f5
DOI: 10.1101/2023.07.10.548412

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