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Article

Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy

4 Feb 2025

Abstract excerpt

MAGEA4 is a member of the Melanoma-Associated Antigen (MAGE) family, characterized by high expression in various tumor tissues but low expression in normal tissues, with the exception of testis and placenta. Its expression is associated with poor prognosis in cancer. This review summarizes the mechanisms of action, regulatory functions, and immunotherapeutic applications of MAGEA4 in cancer.MAGEA4 promotes tumor...

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PMID: 39905312
DOI: 10.1186/s10020-025-01079-8

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