Article

Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

2023-03-29

Abstract excerpt

<h4>Summary</h4> To explore mechanisms of response to combined PD-1/CTLA-4 immune checkpoint blockade (ICB) treatment in individual cell types, we generated scRNA-seq using a mouse model of invasive urothelial carcinoma with three conditions: untreated tumor, treated tumor, and tumor treated after CD4+ T cell depletion. After classifying tumor cells based on detection of somatic variants and assigning non-tumor c...

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Literature Corpus work: 0d15b618-02d1-5249-8eca-a3c12a879d3e
DOI: 10.1101/2023.03.28.534561

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