Article

Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma

2023-10-12

Abstract excerpt

CIC-DUX4 is a rare and understudied transcription factor fusion oncoprotein. CIC-DUX4 co-opts native gene targets to drive a lethal form of human sarcoma. The molecular underpinnings that lead to oncogenic reprograming and CIC-DUX4 sarcomagenesis remain largely undefined. Through an integrative ChIP and RNA-Seq analysis using patient-derived CIC-DUX4 cells, we define CIC-DUX4 mediated chromatin states and function...

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Literature Corpus work: c6a590c5-3828-5d43-b69b-ae7c894202b4
DOI: 10.1101/2023.10.11.561932

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