Back to search

Article

The Central Role of Immune Checkpoint Receptors in Genitourinary Tumor Immunotherapy: Mechanisms, Biomarkers, and Therapeutic Landscape

2025-06-11

Abstract excerpt

Immune checkpoint receptors (ICRs) play a pivotal role in modulating antitumor immunity and have become central targets in the immunotherapy of genitourinary (GU) malignancies. This review provides a comprehensive overview of the fundamental mechanisms of ICR signaling, the expression and pathophysiological roles of these receptors in GU cancers (kidney, bladder, prostate, testicular, and penile), and the evolving...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6b60826a-650d-5a98-8ff2-cd5412338702
DOI
10.20944/preprints202506.0909.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Central Role of Immune Checkpoint Receptors in Genitourinary Tumor Immunotherapy: Mechanisms, Biomarkers, and Therapeutic LandscapeDOI 10.20944/preprints202506.0909.v1
Immune Checkpoint Inhibitor Resistance in Genitourinary Cancers: Mechanisms, Biomarkers, and Emerging Therapeutic StrategiesSemantic proximity
Tumor immune checkpoints and their associated inhibitorsSemantic proximity
Molecular Mechanisms of Targeted Therapy Resistance in Genitourinary Tumors: A Path to New Therapeutic HorizonsSemantic proximity
The Role of YY1 in the Regulation of LAG-3 Expression in CD8 T Cells and Immune Evasion in Cancer: Therapeutic ImplicationsSemantic proximity
A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity
Pan-cancer analysis of immune checkpoint receptors and ligands in various cells in the tumor immune microenvironmentSemantic proximity
Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy.Semantic proximity
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers.Semantic proximity
Oncogenic PIK3CA mutation enhances tumor immunogenicity through the IRF1-NLRC5-MHC-I axis in urothelial carcinoma.Semantic proximity
Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer TherapeuticsSemantic proximity
Differential expression of HAVCR2 gene in pan-cancer: A potential biomarker for survival and immunotherapySemantic proximity
Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivitySemantic proximity
Select a neighboring publication to make it the new centre.