Article

Dihydropyrimidines sustain aggressive cancer states by stabilizing DPYSL2

2026-06-18

Abstract excerpt

Cancer cell states are governed by coordinated signaling and metabolic networks, yet the mechanisms coupling metabolic activity to oncogenic signaling remain poorly understood. Here, we identify dihydropyrimidines (DHPs), metabolites generated during pyrimidine catabolism, as “signaling metabolites” that sustain aggressive cancer cell states. Depletion of DHPs, either by knockout of the pyrimidine catabolic enzyme...

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Literature Corpus work: 1b31a0db-3a82-55ab-b7bd-4aef72361046
DOI: 10.64898/2026.06.14.731825

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