Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.

British journal of cancer - 1 Jan 2021

Siddiqui Mohammad Aarif, Gollavilli Paradesi Naidu, Ramesh Vignesh, Parma Beatrice, Schwab Annemarie, Vazakidou Maria Eleni, Natesan Ramakrishnan, Saatci Ozge, Rapa Ida, Bironzo Paolo, Schuhwerk Harald, Asangani Irfan Ahmed, Sahin Ozgur, Volante Marco, Ceppi Paolo

Abstract excerpt

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT transcription factor ZEB1 in NSCLC and imparts resistance against anti-folate chemotherapy. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Phenotype

Share to Thymidylate Synthase

Source

Open in PubMed Open full text

Identifiers

PMID: 33024270
DOI: 10.1038/s41416-020-01095-x
PMCID: PMC7782507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.PMID 33024270Read ↗

Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial‐to‐mesenchymal transition of cancer cellsSemantic proximity Read ↗

Thymidylate synthase inhibitors for non-small cell lung cancerSemantic proximity Read ↗

Unveiling the oncogenic significance of thymidylate synthase in human cancersSemantic proximity Read ↗

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancersSemantic proximity Read ↗

Unveiling the oncogenic significance of thymidylate synthase in human cancersSemantic proximity Read ↗

Identification of the immune-associated enhancer RNA SATB1-AS1 as a novel biomarker for thymic cancer prognosisSemantic proximity Read ↗

Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expressionSemantic proximity Read ↗

Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.Semantic proximity Read ↗

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution.Semantic proximity Read ↗

Thymidylate synthase (TS) gene expression in primary lung cancer patients: a large-scale study in Japanese populationSemantic proximity Read ↗

Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in non-small cell lung cancerSemantic proximity Read ↗

Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.