Article

Contact-based transfer of thymidylate promotes collective tumor growth

2024-08-01

Abstract excerpt

<h4>Summary</h4> Sustained cell proliferation is a fundamental hallmark of cancer, yet its mechanism remains elusive, particularly in context of heterogenous tumor organization, intercellular interactions, and metabolite exchanges. In this study, we uncover a mechanism of tumor growth via collective proliferation , where cells connected by gap junctions enable equilibration of thymidylate (dTMP) to allow the pro...

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Literature Corpus work: 88e924ab-1934-54ab-a88c-ef4b81f868f2
DOI: 10.1101/2024.07.31.606056

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