Article

QuadCleave: Enzymatic cleavage and analysis of DNA G-quadruplexes

2026-05-16

Abstract excerpt

Prediction of G-quadruplexes (G4), noncanonical DNA secondary structures containing guanine tetrads, can have profound relevance across cancer, neurodegenerative and other genetic diseases, but require experimental validation by instrument intensive methods including CD spectroscopy, fluorescence, NMR, or crystallography. We report a novel, inexpensive, efficient and scalable 2-enzyme system for confirmation of G4...

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Literature Corpus work: 20ffdc1d-dba7-5948-a29c-2f2de74c6512
DOI: 10.64898/2026.05.15.725486

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