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Article

BRIE2: computational identification of splicing phenotypes from single-cell transcriptomic experiments.

Genome biology - 27 Aug 2021

Huang Yuanhua, Sanguinetti Guido

Abstract excerpt

RNA splicing is an important driver of heterogeneity in single cells through the expression of alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic coverage limitations of scRNA-seq technologies make it challenging to associate specific splicing events to cell-level phenotypes. BRIE2 is a scalable computational method that resolves these issues by regressing single-cell...

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PMID: 34452629
DOI: 10.1186/s13059-021-02461-5
PMCID: PMC8393734

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